南蛇藤提取物的抗衰老研究
- 来源：新浪科技 作者：dragon 时间：2008-05-05 22:06:10
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植物学
白雪霏
高二年级
华东师范大学第二附属中学
摘 要
本研究为阐明南蛇藤茎不同提取物的抗衰老作用，利用黑腹果蝇进行了抗衰老实验。结果表明南蛇藤茎提取物对雌雄果蝇的半数死亡时间、平均寿命和平均最高寿命均有显著的延长作用，显示出可能存在有延缓衰老的效应；为了进一步验证南蛇藤提取物的生物学效应，我们也开展了提取物对小白鼠、人胚肺二倍体成纤维细胞的抗衰老实验。我们期望通过分离纯化、生物学测定和化学结构鉴定来获得具有抗衰老活性的有效成分，并从个体水平、细胞水平和分子水平揭示南蛇藤提取物抗衰老的作用机制。南蛇藤资源丰富，可望为开发新型药物以及为中药现代化的发展提供理论依据和基础资料。
The Anti-aging Effect of Celastrus orbiculatus Extract
Botany
Xuefei Bai
Senior Two
No. 2 High School of East China Normal University
ABSTRACT
Celastrus orbiculatus is a resourceful plant. It is expected to be explored as a novel drug, providing the theoretical basis of modernizing traditional Chinese medicine. To investigate the anti-aging effect of Celastrus orbiculatus extract, we employed the fruitfly as research material to study the life-span after the extract treatment. The results showed that the mean life-span and highest life-span of the treated fruitfly were longer than those of the control group. It indicated that Celastrus orbiculatus may possess the anti-ageing effect. For validating the biological effect of Celastrus orbiculatus, the longevity effects on the life - span of human diploid fibroblast and mice were also tested. In order to elucidate the mechanism of the anti-aging effect, we identified the compounds and conducted the research through individual level, cell level and gene level.
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